% a very basic UTE-like sequence, without ramp-sampling, ramp-RF and other % tricks yet. Achieves TE in the range of 300-400 us % set system limits sys = mr.opts('MaxGrad', 28, 'GradUnit', 'mT/m', ... 'MaxSlew', 100, 'SlewUnit', 'T/m/s', 'rfRingdownTime', 20e-6, ... 'rfDeadTime', 100e-6, 'adcDeadTime', 10e-6); seq=mr.Sequence(sys); % Create a new sequence object fov=250e-3; Nx=256; % Define FOV and resolution alpha=10; % flip angle sliceThickness=3e-3; % slice TR=10e-3; % TR Nr=128; % number of radial spokes delta= 2* pi / Nr; % angular increment; try golden angle pi*(3-5^0.5) or 0.5 of it ro_duration=2.56e-3; % read-out time: controls RO bandwidth and T2-blurring ro_os=2; % oversampling ro_asymmetry=1; % 0: fully symmetric 1: half-echo minRF_to_ADC_time=50e-6; % the parameter wich defines TE (together with the RO asymmetyry) % more in-depth parameters % RF spoiling increment = 84° for smoother transient decay, https://doi.org/10.1002/mrm.1910350216, 169° for diffusion independent rf spoiling in steady-state https://doi.org/10.1371/journal.pone.0324455 rfSpoilingInc=84; % RF spoiling increment % Create alpha-degree slice selection pulse and gradient [rf, gz, gzReph] = mr.makeSincPulse(alpha*pi/180,'Duration',1e-3,... 'SliceThickness',sliceThickness,'apodization',0.5,'timeBwProduct',2,... 'centerpos',1,'system',sys, 'use','excitation'); % Align RO assymmetry to ADC samples Nxo=round(ro_os*Nx); ro_asymmetry = round(ro_asymmetry*Nxo/2)/Nxo*2; % check whether we need to use 2Nx or so... % Define other gradients and ADC events deltak=1/fov/(1+ro_asymmetry); ro_area=Nx*deltak; gx = mr.makeTrapezoid('x','FlatArea',ro_area,'FlatTime',ro_duration,'system',sys); adc = mr.makeAdc(Nxo,'Duration',gx.flatTime,'Delay',gx.riseTime,'system',sys); gxPre = mr.makeTrapezoid('x','Area',-(gx.area-ro_area)/2 -gx.amplitude*adc.dwell/2 - ro_area/2*(1-ro_asymmetry),'system',sys); % gradient spoiling gxSpoil=mr.makeTrapezoid('x','Area',0.2*Nx*deltak,'system',sys); % Calculate timing %ceil((TE - mr.calcDuration(gxPre) - gz.fallTime - gz.flatTime/2 ... % - mr.calcDuration(gx)/2)/seq.gradRasterTime)*seq.gradRasterTime; % calculate actual achieved TE TE = gz.fallTime + mr.calcDuration(gxPre,gzReph)+gx.riseTime + adc.dwell*Nxo/2*(1-ro_asymmetry); delayTR=ceil((TR - mr.calcDuration(gxPre,gzReph) - mr.calcDuration(gz) ... - mr.calcDuration(gx))/seq.gradRasterTime)*seq.gradRasterTime; assert(all(delayTR>=mr.calcDuration(gxSpoil))); fprintf('TE= %d us\n', round(TE*1e6)); if mr.calcDuration(gzReph) > mr.calcDuration(gxPre) gxPre.delay=mr.calcDuration(gzReph) - mr.calcDuration(gxPre); end rf_phase=0; rf_inc=0; for i=1:Nr for c=1:2 rf.phaseOffset=rf_phase/180*pi; adc.phaseOffset=rf_phase/180*pi; rf_inc=mod(rf_inc+rfSpoilingInc, 360.0); rf_phase=mod(rf_phase+rf_inc, 360.0); % UTE: alternate GZ gz.amplitude=-gz.amplitude; gzReph.amplitude=-gzReph.amplitude; % seq.addBlock(rf,gz); phi=delta*(i-1); gpc=gxPre; gps=gxPre; gpc.amplitude=gxPre.amplitude*cos(phi); gps.amplitude=gxPre.amplitude*sin(phi); gps.channel='y'; grc=gx; grs=gx; grc.amplitude=gx.amplitude*cos(phi); grs.amplitude=gx.amplitude*sin(phi); grs.channel='y'; gsc=gxSpoil; gss=gxSpoil; gsc.amplitude=gxSpoil.amplitude*cos(phi); gss.amplitude=gxSpoil.amplitude*sin(phi); gss.channel='y'; seq.addBlock(gpc,gps,gzReph); seq.addBlock(grc,grs,adc); seq.addBlock(gsc,gss,mr.makeDelay(delayTR)); end end %% check whether the timing of the sequence is correct [ok, error_report]=seq.checkTiming; if (ok) fprintf('Timing check passed successfully\n'); else fprintf('Timing check failed! Error listing follows:\n'); fprintf([error_report{:}]); fprintf('\n'); end %% %% plot gradients to check for gaps and optimality of the timing gw=seq.waveforms_and_times(); %% k-space trajectory calculation % plot k-spaces % seq.setDefinition('FOV', [fov fov sliceThickness]); seq.setDefinition('Name', 'ute'); seq.write('ute.seq'); % Write to pulseq file